Antithrombin activity of a polyelectrolyte synthesized fromcis-1,4-polyisoprene

Antithrombin activity of a polyelectrolyte synthesized from cis-1,4-polyisoprene.

The antithrombin activity of heparin.

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Direct antimicrobial activity of antithrombin?

a study by Hofstra and colleagues [1] in a recent issue of Critical Care, nebulization of drotrecogin-alfa (activated), antithrombin, heparin, or danaparoid attenuated pulmonary coagulopathy during Streptococcus pneumoniae pneumonia in rats; only antithrombin additionally exerted lung-protective eff ects and reduced bacterial outgrowth. Adding antithrombin to culture medium had no eff ect on th...

Assessing the Antimicrobial Activity of Polyisoprene Based Surfaces

There has been an intense research effort in the last decades in the field of biofouling prevention as it concerns many aspects of everyday life and causes problems to devices, the environment, and human health. Many different antifouling and antimicrobial materials have been developed to struggle against bacteria and other micro- and macro-organism attachment to different surfaces. However the...

Anti-HSV activity of serpin antithrombin III.

Natural serine protease inhibitors (serpins) elicit sensing of a microbial cell intruder and activate an intrinsic cellular immune response in HIV and HCV infected cells. Here, we demonstrate in vitro inhibition of HSV with serpin antithrombin III (ATIII) early during infection pointing towards inhibition of an entry event. We also found reduction of mortality from 90% to 40% in an abrasion mic...